Pros and Cons of Weight Loss Injections

Weight loss injections like Wegovy (semaglutide), Ozempic (semaglutide), and Mounjaro (tirzepatide) have gained popularity in the UK for aiding weight management and treating type 2 diabetes. 

These medications function by mimicking hormones that regulate appetite and digestion, leading to reduced calorie intake and weight loss.

How Do Weight Loss Injections Work?

These drugs are primarily GLP-1 receptor agonists, which imitate the glucagon-like peptide-1 hormone. This hormone stimulates insulin secretion, suppresses appetite by signaling satiety to the brain, and slows gastric emptying, prolonging the feeling of fullness. 

Tirzepatide, found in Mounjaro, also targets GIP receptors, enhancing its appetite-suppressing effects .

Are They Safe?

Clinical trials have demonstrated that these injections can lead to significant weight loss—up to 20% of body weight in some cases—and may reduce the risk of heart attacks, strokes, and complications from type 2 diabetes. But they aren't without risks.

Common side effects include nausea,vomiting, diarrhoea, constipation and heartburn.

Serious Risks include pancreatitis gallbladder disease, kidney problems, gastroparesis (delayed stomach emptying) and animal studies indicated that thyroid tumours could be a risk.

Some users have reported mental health concerns, including depression and anxiety, though evidence on this is still emerging.

Are There Long-Term Side Effects?

Long-term data is still being collected, but some users have reported persistent side effects even after discontinuing the medication. These include ongoing gastrointestinal issues, hair loss and dizziness. The potential for long-term complications such as thyroid tumours and gallbladder disease necessitates careful monitoring.

Final Thoughts

Weight loss injections offer a promising option for individuals struggling with obesity and related health issues. However, they are not a one-size-fits-all solution and come with potential risks. It's crucial to consult with a healthcare professional to determine if these medications are appropriate for your situation and to ensure proper monitoring during treatment.

For further information on the benefits and risks of weight loss injections, you can refer to the British Heart Foundation's overview here https://www.bhf.org.uk/informationsupport/heart-matters-magazine/news/behind-the-headlines/weight-loss-injections