Pros and Cons of Weight Loss Injections

Weight loss injections like Wegovy (semaglutide), Ozempic (semaglutide), and Mounjaro (tirzepatide) have gained popularity in the UK for aiding weight management and treating type 2 diabetes. 

These medications function by mimicking hormones that regulate appetite and digestion, leading to reduced calorie intake and weight loss.

How Do Weight Loss Injections Work?

These drugs are primarily GLP-1 receptor agonists, which imitate the glucagon-like peptide-1 hormone. This hormone stimulates insulin secretion, suppresses appetite by signaling satiety to the brain, and slows gastric emptying, prolonging the feeling of fullness. 

Tirzepatide, found in Mounjaro, also targets GIP receptors, enhancing its appetite-suppressing effects .

Are They Safe?

Clinical trials have demonstrated that these injections can lead to significant weight loss—up to 20% of body weight in some cases—and may reduce the risk of heart attacks, strokes, and complications from type 2 diabetes. But they aren't without risks.

Common side effects include nausea,vomiting, diarrhoea, constipation and heartburn.

Serious Risks include pancreatitis gallbladder disease, kidney problems, gastroparesis (delayed stomach emptying) and animal studies indicated that thyroid tumours could be a risk.

Some users have reported mental health concerns, including depression and anxiety, though evidence on this is still emerging.

Are There Long-Term Side Effects?

Long-term data is still being collected, but some users have reported persistent side effects even after discontinuing the medication. These include ongoing gastrointestinal issues, hair loss and dizziness. The potential for long-term complications such as thyroid tumours and gallbladder disease necessitates careful monitoring.

Final Thoughts

Weight loss injections offer a promising option for individuals struggling with obesity and related health issues. However, they are not a one-size-fits-all solution and come with potential risks. It's crucial to consult with a healthcare professional to determine if these medications are appropriate for your situation and to ensure proper monitoring during treatment.

For further information on the benefits and risks of weight loss injections, you can refer to the British Heart Foundation's overview here https://www.bhf.org.uk/informationsupport/heart-matters-magazine/news/behind-the-headlines/weight-loss-injections

Weight loss injections. Do they work? How much are they?

In recent years, weight loss injections have emerged as a significant tool in combating obesity in the UK. 

Medications like Wegovy, Saxenda, and Mounjaro have gained attention for their effectiveness in aiding weight reduction when combined with lifestyle changes. 

This article explores the companies offering these treatments, their efficacy, safety profiles, and associated costs.​

Companies Offering Weight Loss Injections in the UK

Several pharmaceutical companies and healthcare providers offer weight loss injections:​

Wegovy (Semaglutide): Manufactured by Novo Nordisk, Wegovy has been approved by the National Institute for Health and Care Excellence (NICE) for use within the NHS. It is also available through private healthcare providers.​

Saxenda (Liraglutide): Also produced by Novo Nordisk, Saxenda is accessible via the NHS for individuals meeting specific criteria and can be obtained privately.​

Mounjaro (Tirzepatide): Developed by Eli Lilly, Mounjaro is available through private clinics and online pharmacies in the UK.​

Effectiveness of Weight Loss Injections

Clinical studies have demonstrated the efficacy of these medications:​

Wegovy: In a 68-week trial, participants experienced an average weight loss of 15.8% of their initial body weight. ​

Saxenda: The same study reported a mean weight loss of 6.4% over 68 weeks. ​

Mounjaro: Clinical trials have shown weight reductions ranging from 15% to 20% of initial body weight. ​

Safety and Side Effects

While effective, these injections may cause side effects, typically mild but diminishing over time:​

Common Side Effects: Nausea, diarrhoea, constipation, headache, fatigue, dizziness, stomach pain, and upset stomach. ​

Serious Risks: Rare but severe side effects can include pancreatitis. Users are advised to consult healthcare professionals for personalised advice and monitoring. ​

Cost of Weight Loss Injections

The cost varies depending on the medication and provider:​

thedietologist.co.uk

Wegovy: NICE lists prices ranging from £124.54 to £175.80 per pack, depending on the dosage. ​

Saxenda: Approximately £196.20 for a pack of five 3ml pens. ​

Mounjaro: Prices start from £188.99 per pen. ​

These treatments may be available on the NHS for individuals meeting specific criteria; otherwise, they can be accessed through private healthcare channels.​

However, some local NHS Trusts routinely decline to prescribe weight loss injections on cost grounds, often blaming dubious 'clinical reasons.'

Conclusion

Weight loss injections like Wegovy, Saxenda, and Mounjaro offer promising avenues for individuals struggling with obesity. While they have shown significant effectiveness, it is crucial to consider potential side effects and consult healthcare providers to determine the most appropriate treatment plan. Costs can be substantial, but eligibility for NHS coverage may alleviate financial burdens for some patients.