Touted as a quick fix for stubborn fat, these injections are often marketed in clinics and medispas, and are even discussed in GP consultations when patients express concerns about body image or weight management.
But while the physical effects may seem subtle and appealing, there are several side-effects, some overlooked even by general practitioners, that are important to consider.
What Are Fat-Reducing Injections?
Fat-dissolving injections work by breaking down fat cell membranes, allowing the body to absorb and naturally dispose of the released fat. Typically used for areas such as double chins, thighs, or love handles, they can seem like an ideal solution for those looking to sculpt their bodies without invasive surgery.
However, these injections are not without risks, and not all side-effects are well-known or routinely discussed.
Side-Effects GPs Might Miss or Underestimate
1. Prolonged Swelling and Inflammation
While mild swelling is expected, some patients experience inflammation that lasts for several weeks. In certain cases, it can lead to the development of firm lumps under the skin, which may take months to resolve—or might require intervention.
2. Nerve Damage
Deoxycholic acid can, if injected incorrectly or in overly high quantities, damage surrounding nerves. This could result in:
Numbness
Muscle weakness
Tingling or shooting pain
Such side-effects can be temporary, but some patients report lingering issues, especially when injections are administered without ultrasound guidance or appropriate anatomical knowledge.
3. Skin Necrosis
In rare but serious cases, compromised blood flow from the injection can cause the surrounding skin tissue to die (necrosis). This is more likely when fat-dissolving injections are used off-label or administered by poorly trained practitioners.
4. Hormonal Implications
Although less documented in official guidance, anecdotal evidence and emerging studies suggest that disrupting fat cells may have minor hormonal ripple effects, particularly for those with existing hormonal imbalances such as PCOS or thyroid conditions. Some GPs may not yet be attuned to these interactions.
5. Immune Responses
Some patients experience immune system overreactions, such as persistent itching, rashes, or autoimmune flare-ups. While these are relatively rare, they are not always linked back to the injections—especially if they occur weeks after the procedure.
6. Emotional and Psychological Side-Effects
Changing one’s appearance, even slightly, can have a significant psychological impact. Patients with underlying body dysmorphia or disordered eating behaviours may find themselves fixated on further "problem areas," leading to an unhealthy spiral of repeat procedures or poor self-image. GPs without specific training in aesthetic medicine may overlook this risk.